Selective gamma-secretase inhibitor blocks substrate on amyloid precursor protein. Credit: Rensselaer Polytechnic Institute New gamma secretase inhibitor blocks only amyloid production, no other functions. A…
Posts published in “Alzheimer’s”
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Using cryo-electron microscopy, Furukawa’s lab compiled a 3D image detailing the exact arrangement of the proteins that shape each CALHM pore. Pictured: CALHM1 as seen…
Amyloid-beta (green fluorescence) and aluminum (orange fluorescence) in senile plaque from brain tissue of a familial Alzheimer’s disease donor. Credit: Neurobiology, University of Texas at…
A preventive treatment for dementia may proceed to clinical trials after successful animal testing. Possible dementia vaccine closer after mice studies; Human trials tipped within…
Mouse study connects body clock and memory recall. Can’t remember something? Try waiting until later in the day. Researchers identified a gene in mice that…
[embedded content] MIT neuroscientists in the lab of Professor Li-Huei Tsai at The Picower Institute for Learning and Memory are studying whether sensory stimulation —…
Dr. Corrado Cali explores 3D reconstructions of extremely complex brain cells known as astrocytes, a key cell involved in memory formation and learning, within KAUST’s…
Clip from the Human Amyloid Buildup video below. Credit: The Picower Institute for Learning and Memory Long before symptoms like memory loss even emerge, the…
Microglia are specialized cells that work to clear away debris in the brain and perform other essential duties. These cells typically become dysregulated in Alzheimer’s…
A drug commonly used to manage symptoms of Alzheimer disease and other dementias — donepezil — is associated with a two-fold higher risk of hospital…
Why neuron-like implants could offer a better way to treat Alzheimer’s disease or post-traumatic stress disorder, control prosthetics, or even enhance cognitive abilities. Recently, Charles…
The blood-brain barrier — the normally tight border that prevents harmful molecules in the bloodstream from entering the brain — can be damaged by the…
Proteins in the fluid surrounding the target cell bind to a virus and can make it more infectious. The virus can also accelerate the formation…
Amyloid beta plaques accumulated in a mouse hippocampus. Yale researchers have identified a drinkable cocktail of designer molecules that interferes with a crucial first step…