A team of U.S. scientists has developed an AI-based system capable of detecting signs of life with 90% accuracy. This system can distinguish between biological and abiotic materials. It holds significant implications for understanding life’s origins on Earth and Mars and detecting extraterrestrial life, potentially transforming astrobiology.
The system demonstrates 90% accuracy in distinguishing between biological and non-biological samples.
Humankind is looking for life on other planets, but how will we recognize it when we see it? Now a team of scientists in the United States has created an artificial intelligence system capable of identifying signs of life on other planets with 90% accuracyHow close the measured value conforms to the correct value.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>accuracy.
The work was recently presented to scientists for the first time at the Goldschmidt Geochemistry Conference in Lyon on Friday 14th July, where it received a positive reception from others working in the field. The details have also been recently published in the peer-reviewed journal PNAS.
Lead researcher Professor Robert Hazen, of the Carnegie Institution’s Geophysical Laboratory and George Mason University. said “This is a significant advance in our abilities to recognize biochemical signs of life on other worlds. It opens the way to using smart sensors on unmanned spaceships to search for signs of life.”
Since the early 1950s, scientists have known that given the right conditions, mixing simple chemicals can form some of the more complex molecules required for life, such as amino acids<div class="cell text-container large-6 small-order-0 large-order-1">
<div class="text-wrapper"><br />Amino acids are a set of organic compounds used to build proteins. There are about 500 naturally occurring known amino acids, though only 20 appear in the genetic code. Proteins consist of one or more chains of amino acids called polypeptides. The sequence of the amino acid chain causes the polypeptide to fold into a shape that is biologically active. The amino acid sequences of proteins are encoded in the genes. Nine proteinogenic amino acids are called "essential" for humans because they cannot be produced from other compounds by the human body and so must be taken in as food.<br /></div>
</div>” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>amino acids. Since then, many more of the components necessary for life, such as the nucleotides needed to make DNADNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>DNA, have been detected in space. But how do we know if these are of biological origin, or if they are made by another abiotic process over time. Without knowing that, we don’t know if we have detected life.
A selfie, taken by the Curiosity rover on the surface of Mars in June 2016. The Curiosity rover used the pyrolysis-GCMS equipment described in this notice. Credit: NASA/JPL-Caltech/MSSS
Bob Hazen said “We are asking a fundamental question; Is there something fundamentally different about the chemistry of life compared to the chemistry of the inanimate world? Are there “chemical rules of life” that influence the diversity and distribution of biomolecules? Can we deduce those rules and use them to guide our efforts to model life’s origins or to detect subtle signs of life on other worlds? We found that there is.
From an evolutionary point of view, life is not an easy thing to sustain, and so there are certain pathways that work and certain that don’t. Our analysis does not rely on absolute identification of a compound but determines biological/non-biological origins by looking at the compound in relation to the sample context.”
What they did
The scientists employed NASAEstablished in 1958, the National Aeronautics and Space Administration (NASA) is an independent agency of the United States Federal Government that succeeded the National Advisory Committee for Aeronautics (NACA). It is responsible for the civilian space program, as well as aeronautics and aerospace research. Its vision is "To discover and expand knowledge for the benefit of humanity." Its core values are "safety, integrity, teamwork, excellence, and inclusion." NASA conducts research, develops technology and launches missions to explore and study Earth, the solar system, and the universe beyond. It also works to advance the state of knowledge in a wide range of scientific fields, including Earth and space science, planetary science, astrophysics, and heliophysics, and it collaborates with private companies and international partners to achieve its goals.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>NASA flight-tested pyrolysis gas-chromatography mass-spectrometry (GCMS) methods to analyze 134 varied carbon-rich samples from living cells, age-degraded samples, geologically processed fossil fuels, Carbon-rich meteorites, and laboratory-synthesized organic compounds and mixtures.
59 of these were of biological origin (biotic), such as a grain of rice, a human hair, crude oil, etc. 75 were of non-biological origin (abiotic), such as lab-synthesized compounds like amino acids, or samples from carbon-rich meteorites. The samples were first heated in an oxygen-free environment, which causes the samples to break down (a process known as pyrolysis).
The treated samples were then analyzed in a GC-MS, an analytical device that separates the mixture into its component parts, and then identifies them. Using a suite of machine-learning methods, three-dimensional (time/intensity/mass) data from each abiotic or biotic sample were employed as training or testing subsets, which resulted in a model that can predict the abiotic or biotic nature of the sample with greater than 90 percent accuracy.
The first presentation and feedback from other scientists
Professor Hazen presented the work for the first time to scientists at the Goldschmidt geochemistry conference in Lyon, France, on 14th July, as part of a session looking at geobiology of life on Earth and other planetary systems.
In response to questions from the audience, Professor Hazen confirmed that “The team will be able to expand the range of biosignatures, to detect extraterrestrial life, which may be fundamentally different to life on Earth.”
Session co-chairs, Anastasia Yanchilina (Impossible Sensing, St Louis), and Fabian Gäb (University of Bonn) noted that the in-person feedback from the attending scientists was lively and positive.
Dr. Yanchilina said, “The session as a whole went well, and this talk was one of the cherries on the cake. This moves us closer to recognizing life when we find it.”
What it means
Professor Hazen continued “There are some interesting and deep implications which flow from this work. First, we can apply these methods to ancient samples from Earth and MarsMars is the second smallest planet in our solar system and the fourth planet from the sun. It is a dusty, cold, desert world with a very thin atmosphere. Iron oxide is prevalent in Mars' surface resulting in its reddish color and its nickname "The Red Planet." Mars' name comes from the Roman god of war.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>Mars, to find out if they were once alive. This is obviously important for looking at whether there was life on Mars, but it can also help us analyze very ancient samples from Earth, to help us understand when life first began.
It also means that at a deep level, biochemistry and non-biological chemistry are somehow different. This probably also means that we may be able to tell a lifeform from another planet, from another biosphere, from the ones we know on Earth. This means that if we find life elsewhere, we can tell if life on Earth and other planets came from a common origin (panspermia), or whether they would have come from different origins.
What really astonished us was that we trained our machine-learning method on only two attributes–biotic or abiotic–but the method discovered 3 distinct populations–abiotic, living biotic, and fossil biotic – in other words, it could tell fossil samples from more recent biological samples. This surprising finding gives us optimism that other attributes such as photosynthetic life or eukaryotes (cells with a nucleus) might also be distinguished.
In summary, this study is just the beginning of what may become a widely useful approach to teasing out information from enigmatic organic mixtures.”
Commenting, Professor Emmanuelle Javaux (Head of Early Life Traces and Evolution-Astrobiology lab, Director of Research unit Astrobiology, University of Liège, Belgium) said:
“I think this new study is very exciting. It is a new avenue of research to explore as it appears to discriminate abiotic from biotic organic matter based on its molecular complexity and could potentially be a fantastic tool for astrobiology missions. It would also be very interesting to test this new method on some of the oldest putative and debated traces of Earth life as well as on modern and fossil organisms from the three domains of life! this might help to solve some hot debates in our community.”
This is an independent comment, Professor Javaux was not involved in this work.
Reference: “A robust, agnostic molecular biosignature based on machine learningMachine learning is a subset of artificial intelligence (AI) that deals with the development of algorithms and statistical models that enable computers to learn from data and make predictions or decisions without being explicitly programmed to do so. Machine learning is used to identify patterns in data, classify data into different categories, or make predictions about future events. It can be categorized into three main types of learning: supervised, unsupervised and reinforcement learning.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>machine learning” by H. James Cleaves, Grethe Hystad, Anirudh Prabhu, Michael L. Wong, George D. Cody, Sophia Economon and Robert M. Hazen, 25 September 2023, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2307149120
Conference Abstract 18592 A Robust Molecular Biosignature Based on Machine Learning Applied to Three-Dimensional Pyrolysis GCMS Data
Henderson Cleaves – Blue Marble Space Institute; Grethe Hystad – Purdue University Northwest; Anirudh Prabhu, Michael Wong, George Cody, Robert Hazen (all Carnegie Institution for ScienceThe Carnegie Institution for Science is a private, nonprofit organization based in Washington, D.C. that conducts scientific research and education. It was founded in 1902 by Andrew Carnegie and is one of the oldest independent research institutions in the United States. The Carnegie Institution for Science includes six research departments: Embryology, Observatories, Plant Biology, Global Ecology, Terrestrial Magnetism, and DTM (Department of Terrestrial Magnetism). It also has a number of affiliated programs and initiatives, including the Carnegie Academy for Science Education and the Carnegie Institution for Science's Department of Global Ecology.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>Carnegie Institution for Science); Sophia Economon – Johns Hopkins University
The search for definitive biosignatures—unambiguous markers of past or present life—remains a central goal of astrobiology. Our hypothesis is that deeply-rooted aspects of biochemistry differ fundamentally from the chemistry of the nonliving world. Unlike molecules in nonliving systems, life’s carbon-based molecular building blocks must be selected for their functions, including to store and replicate information, gather energy and atoms, build structures, control environments, and more. Making functional biomolecules requires energy and information—precious commodities in a competitive Darwinian world. Therefore, we suggest that the diversity and distribution of organic molecules in living systems are different from organic molecular suites produced by abiotic processes, because the biological processes of selection for function and efficient synthesis pathways lead to different frequency distributions of biotic molecules compared to what emerges from purely abiotic processes.
We employed NASA flight-tested pyrolysis gas-chromatography mass-spectrometry (GCMS) methods to analyze 134 varied carbon-rich samples from living cells, taphonomically-degraded samples, geologically processed fossil fuels, C-rich meteorites, and laboratory-synthesized organic compounds and mixtures. Using a suite of machine-learning methods, three-dimensional (time/intensity/mass) data from each abiotic or biotic sample were employed as training or testing subsets, which resulted in a model that can predict the abiotic or biotic nature of the sample with greater than 90 percent accuracy. Furthermore, samples from living cells, geologically-processed biota, and abiotic mixtures reveal discrete attributes that point to the possibility of more granular identification of organic-rich samples (see Figures). Implications include: (1) we can apply this method to Mars and ancient Earth samples to tell if they were once alive; (2) at some deep level biochemistry differs from abiotic organic chemistry; and (3) because of the nature of the method, it is likely that it could distinguish alternative biospheres from that of Earth.
Source: SciTechDaily
