A study published in The American Journal of Clinical Nutrition, involving 573 older adults, found that cocoa extract supplements improved cognition in participants with poor diets but had no effect on those with healthy diets. The research is part of the larger COSMOS trial exploring the health impacts of supplements.
Recent research shows cocoa extract supplements may benefit cognition in older adults with poor diets, but not in those with healthy diets, according to a study within the larger COSMOS trial.
Cocoa extract has shown a potential protective effect on cognition but randomized clinical trials in older adults have had inconsistent results. A new study of cognition in a randomized trial, known as the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS), suggests that taking cocoa extract supplements containing 500 mg per day of cocoa flavanols had cognitive benefits for older adults who had lower habitual diet quality at the time of enrollment in the study. However, cognitive benefits were not found among participants who already had healthy dietary patterns at the start of the study.
The study, conducted by researchers at Mass General Brigham, included 573 older adults who underwent detailed, in-person cognitive testing and was published on December 7 in The American Journal of Clinical NutritionThe American Journal of Clinical Nutrition (AJCN) is a monthly peer-reviewed biomedical journal in the fields of dietetics and clinical nutrition. Initially established as the Journal of Clinical Nutrition in 1952, when it was published by the Nutrition Press, it is currently published by the American Society for Nutrition.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>American Journal of Clinical Nutrition.
Study Findings
Results from detailed neuropsychological assessments given over two years showed that daily cocoa extract supplementation, compared to placebo, had no overall benefits for global or domain-specific cognitive function. However, secondary analyses showed that participants with poor diet quality had cognitive benefits from taking the cocoa extract supplement.
The findings from this study – which was done among COSMOS participants who presented in-person for detailed cognitive testing – are consistent with the results from an earlier study that used a web-based cognitive assessment given over the internet to a separately recruited set of COSMOS participants.
COSMOS Trial and Broader Implications
COSMOS is an investigator-initiated large-scale, long-term clinical trial led by Brigham and Women’s Hospital. More than 21,000 older women and men were enrolled across the United States to participate in this randomized, double-blinded, placebo-controlled study to test whether taking daily supplements of a cocoa extract or a common multivitamin reduces the risk for developing heart disease, stroke, cancer, and other important health outcomes. Analyses of the data from COSMOS continue to yield insights about the connections between supplements and human health.
Reference: “Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial” by Chirag M. Vyas, JoAnn E. Manson, Howard D. Sesso, Pamela M. Rist, Alison Weinberg, Eunjung Kim, M Vinayaga Moorthy, Nancy R. Cook and Olivia I. Okereke, 7 December 2023, The American Journal of Clinical Nutrition.
DOI: 10.1016/j.ajcnut.2023.10.031
The study was led by Mass General Brigham researchers, Dr. Chirag Vyas and Dr. Olivia I. Okereke at Massachusetts General Hospital, and Dr. Howard Sesso and Dr. JoAnn Manson at Brigham and Women’s Hospital.
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is supported by an investigator-initiated grant from MarsMars is the second smallest planet in our solar system and the fourth planet from the sun. It is a dusty, cold, desert world with a very thin atmosphere. Iron oxide is prevalent in Mars' surface resulting in its reddish color and its nickname "The Red Planet." Mars' name comes from the Roman god of war.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>Mars Edge, a segment of Mars dedicated to nutrition research and products, which included infrastructure support and the donation of study pills and packaging. Pfizer Consumer Healthcare (now Haleon) provided support through the partial provision of study pills and packaging. COSMOS is also supported in part by grants AG050657, AG071611, EY025623, and HL157665 from the National Institutes of HealthThe National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. Founded in 1887, it is a part of the U.S. Department of Health and Human Services. The NIH conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. With 27 different institutes and centers under its umbrella, the NIH covers a broad spectrum of health-related research, including specific diseases, population health, clinical research, and fundamental biological processes. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>National Institutes of Health, Bethesda, MD. The Women’s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005. Neither Mars Edge nor Pfizer Consumer Healthcare provided input regarding data analyses, interpretation of results, or manuscript development.
Source: SciTechDaily
