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First-of-Its-Kind Study: Plant-Based Diets Improve Metabolic, Liver, and Kidney Health

A study reveals that a healthy plant-based diet, involving reduced intake of processed and sugary foods, can decrease the risk of type 2 diabetes by 24% by improving metabolism and organ function.

A plant-based diet has been proven for the first time to improve metabolism and liver and kidney function.

With limitations – as demonstrated in a study led by Tilman Kühn from MedUni Vienna’s Center for Public Health: A more plant-based diet only develops its protective effects if not only the consumption of animal-based foods, but also industrially processed and highly sugary foods is reduced.

For the first time, the scientists identified improvements in metabolism and liver and kidney function as reasons for the positive effects of a healthy plant-based diet, in addition to the associated lower likelihood of obesity. The study results were recently published in the journal Diabetes & Metabolism.

According to analyses by the research team, a healthy plant-based diet with plenty of fresh fruit and vegetables and wholemeal products reduces the risk of diabetes by 24 percent, even in the presence of a genetic predisposition and other diabetes risk factors such as obesity, advanced age or a lack of physical activity.

Unhealthy plant-based diets with a high proportion of sweets, refined grains, and sugary drinks, on the other hand, are associated with an increased risk of type 2 diabetes.  

Key biomarkers identified

The research was carried out with 113,097 participants in the large-scale British cohort study (UK Biobank) over an observation period of twelve years. According to their findings, the reasons behind the anti-diabetic effect of a healthy plant-based diet go far beyond the well-known lower body fat percentage and waist circumference.

“Our study is the first to identify biomarkers of central metabolic processes and organ functions as mediators of the health effects of a plant-based diet,” says Tilman Kühn, Professor of Public Health Nutrition at MedUni Vienna and the University of Vienna, who led the study in close collaboration with researchers from Queen’s University Belfast.

The investigations confirmed that normal values for blood lipids (triglycerides), blood sugar (HbA1c), inflammatory parameters (CRP), and the insulinInsulin is a hormone that regulates the level of glucose (sugar) in the blood. It is produced by the pancreas and released into the bloodstream when the level of glucose in the blood rises, such as after a meal. Insulin helps to transport glucose from the bloodstream into the cells, where it can be used for energy or stored for later use. Insulin also helps to regulate the metabolism of fat and protein. In individuals with diabetes, their body doesn't produce enough insulin or doesn't respond properly to insulin, leading to high blood sugar levels, which can lead to serious health problems if left untreated.” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>insulin-like growth factor (IGF1) are associated with a low risk of diabetes.

Further benefits discovered

It has also been demonstrated how important the full function of the liver and kidneys is in diabetes prevention. Both organs play a major role in people who already have diabetes.

“However, our research has now shown that a healthy plant-based diet can improve liver and kidney function and thus reduce the risk of diabetes,” says Kühn, outlining a previously underestimated benefit of a conscious plant-based diet.

Reference: “A healthful plant-based diet is associated with lower type 2 diabetes risk via improved metabolic state and organ function: A prospective cohort study” by Alysha S. Thompson, Catharina J. Candussi, Anna Tresserra-Rimbau, Amy Jennings, Nicola P. Bondonno, Claire Hill, Solomon A. Sowah, Aedín Cassidy and Tilman Kühn, 28 November 2023, Diabetes & Metabolism.
DOI: 10.1016/j.diabet.2023.101499

Source: SciTechDaily